Bronx High School of Science is part of a group of schools with Specialized High School status from the NYC Department of Education. The schools serve the needs of gifted New York City Students. This selective public high school emphasizes a college preparatory curriculum with courses in foreign language, fine arts, math, English, social studies, and science. The school teaches eight foreign languages. Required classes include drama, health, and visual arts.

In addition to the fast-paced science and math curriculum offered by the Bronx High School of Science, every student takes a writing seminar and a research literacy course in the ninth grade. While the school is known for its math and science focus, the high school also gives a priority to social sciences and the humanities. Many of the classes include hands-on learning. Students perform independent research in social, physical, and biological sciences.